Tert-butyl((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate

Lorlatinib Intermediate

Lorlatinib (PF-06463922) is a potent, dual ALK/ROS1inhibitor, with K_is of 0.02 nM, 0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALK-L1196M, respectively.